Powdered Wound Dressing Materials Made from wild Silkworm Antheraea pernyi Silk Fibroin on Full-skin Thickness Burn Wounds on Rats
김민근, 유기연, 권광준, 김성곤, 박영욱, 이광길, 조유영, 권해용,
소속 상세정보
김민근 ( Kim Min-Keun ) - Gangneung-Wonju National University College of Dentistry Department of Oral and Maxillofacial Surgery
유기연 ( Yoo Ki-Yeon ) - Gangneung-Wonju National University College of Dentistry Department of Oral Anatomy
권광준 ( Kwon Kwang-Jun ) - Gangneung-Wonju National University College of Dentistry Department of Oral and Maxillofacial Surgery
김성곤 ( Kim Seong-Gon ) - Gangneung-Wonju National University College of Dentistry Department of Oral and Maxillofacial Surgery
박영욱 ( Park Young-Wook ) - Gangneung-Wonju National University College of Dentistry Department of Oral and Maxillofacial Surgery
이광길 ( Lee Kwang-Gill ) - Rural Development Administration National Academy of Agricultural Science Sericultural & Apicultural Materials Division
조유영 ( Jo You-Young ) - Rural Development Administration National Academy of Agricultural Science Sericultural & Apicultural Materials Division
권해용 ( Kweon Hae-Yong ) - Rural Development Administration National Academy of Agricultural Science Sericultural & Apicultural Materials Division
KMID : 1036320140360030111
Abstract
Purpose: This study evaluated powdered burn wound dressing materials from wild silkworm fibroin in an animal model.
Methods: Fifteen rats were used in this experiment. Full-thickness 2×2 cm burn wounds were created on the back of rats under anesthesia. In the two experimental groups, the wounds were treated with two different dressing materials made from silkworm fibroin. In the Control Group, natural healing without any dressing material was set as control. The wound surface area was measured at five days, seven days and 14 days. Wound healing was evaluated by histologic analysis.
Results: By gross observation, there were no infections or severe inflammations through 14 days post-injury. The differences among groups were statistically significant at seven days and 14 days, postoperatively (P <0.037 and 0.001, respectively). By post hoc test, the defect size was significantly smaller in experimental Group 1 compared with the Control Group and experimental Group 2 at seven days postoperatively (P =0.022 and 0.029, respectively). The difference between Group 1 and Group 2 was statistically significant at 14 days postoperatively (P <0.001). Group 1 and control also differed significantly (P =0.002). Group 1 showed a smaller residual scar than the Control Group and Group 2 at 14 days post-injury. Histologic analysis showed more re-epithelization in Groups 1 and 2 than in the Control Groups.
Conclusion: Burn wound healing was accelerated with silk fibroin spun by wild silkworm Antheraea pernyi. There was no atypical inflammation with silk dressing materials. In conclusion, silk dressing materials can be used for treatment of burn wound.
키워드
Full thickness burn wound; Wound dressing; Silk fibroin; Antheraea pernyi; Rats
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